Abstract
The syntheses and SAR studies of various quinazolinone compounds are described for the dual inhibition of Pgp and MRP1 in multidrug resistance.
MeSH terms
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ATP Binding Cassette Transporter, Subfamily B, Member 1 / antagonists & inhibitors*
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Antibiotics, Antineoplastic / antagonists & inhibitors
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Antibiotics, Antineoplastic / pharmacokinetics
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Antineoplastic Agents / antagonists & inhibitors
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Antineoplastic Agents / pharmacokinetics
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Daunorubicin / antagonists & inhibitors
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Daunorubicin / pharmacokinetics
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Doxorubicin / antagonists & inhibitors
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Doxorubicin / pharmacokinetics
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Drug Interactions
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Drug Resistance, Multiple*
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Humans
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Inhibitory Concentration 50
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Quinazolines / chemical synthesis*
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Quinazolines / chemistry
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Quinazolines / pharmacology
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Structure-Activity Relationship
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Tumor Cells, Cultured
Substances
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ATP Binding Cassette Transporter, Subfamily B, Member 1
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Antibiotics, Antineoplastic
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Antineoplastic Agents
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Quinazolines
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Doxorubicin
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Daunorubicin